

@article {9992,
	title = {{Mechanisms of inactivation of hepatitis A virus in water by chlorine dioxide.}},
	journal = {Water research},
	volume = {38},
	number = {6},
	year = {2004},
	month = {mar},
	pages = {1514{\textendash}9},
	abstract = {In this study, to elucidate the mechanisms of inactivation of hepatitis A virus (HAV) by chlorine dioxide, cell culture, enzyme-linked immunosorbent assay (ELISA), and long-overlapping RT-PCR were used to detect the infectivity, antigenicity, and entire genome of HAV before and after disinfection. The results revealed the complete inactivation of infectivity after a 10-min exposure to 7.5mg of chlorine dioxide per liter; and the highest level of sensitivity in the 5{\textquoteright}non-translated regions (5{\textquoteright}NTR) (the sequence from bp 1 to 671), inactivation of which took as much time as the inactivation of infectivity of HAV by chlorine dioxide; the complete destruction of antigenicity after a 10-min exposure to 7.5mg of chlorine dioxide per liter. It is suggested that the inactivation mechanism of HAV by chlorine dioxide was due to the loss of the 5{\textquoteright}NTR and/or destruction of the antigenicity, which is not similar to that of chlorine (Appl Environ Microbiol 68: 4951).},
	keywords = {Chlorine Compounds, Chlorine Compounds: pharmacology, Dental Disinfectants, Dental Disinfectants: pharmacology, DNA, DNA Damage, Enzyme-Linked Immunosorbent Assay, Hepatitis A virus, Human, Human: pathogenicity, Oxides, Oxides: pharmacology, Reverse Transcriptase Polymerase Chain Reaction, Viral, Viral: analysis, Water Purification, Water Purification: methods},
	issn = {0043-1354},
	doi = {10.1016/j.watres.2003.12.021},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15016528},
	author = {Li, Jun Wen and Xin, Zhong Tao and Wang, Xin Wei and Zheng, Jin Lai and Chao, Fu Huan}
}
