

@article {9985,
	title = {{Clinical and Molecular Epidemiology of Human Bocavirus in Respiratory and Fecal Samples from Children in Hong Kong}},
	journal = {The Journal of Infectious Diseases},
	volume = {196},
	number = {7},
	year = {2007},
	pages = {986{\textendash}993},
	abstract = {BACKGROUND: Human bocavirus (HBoV) is a recently discovered parvovirus associated with respiratory tract infections in children. We conducted the first systematic prospective clinical and molecular study using nasopharyngeal aspirates (NPAs) and fecal samples. METHODS: NPAs negative for influenza virus, parainfluenza virus, respiratory syncytial virus, adenovirus, and coronavirus and fecal samples from patients with acute gastroenteritis were included. On the basis of results from a pilot study using 400 NPAs from all age groups, a prospective 12-month study was conducted to detect HBoV in 1,200 NPAs and 1,435 fecal samples from patients {\textless}18 years old by polymerase chain reaction. The complete genome sequences of HBoVs from 12 NPAs and 12 fecal samples were determined. RESULTS: Of the 400 NPAs collected in the pilot study, 20 (5.0{\%}) were found to contain HBoV, all from children {\textless}5 years old. In the subsequent prospective study of pediatric patients, HBoV was detected in 83 (6.9{\%}) of 1,200 NPAs. Upper and lower respiratory tract infections were equally common. HBoV was detected in 30 (2.1{\%}) of 1,435 fecal samples. Fever and watery diarrhea were the most common symptoms. The seasonality of HBoV in NPAs and fecal samples was similar. Codetection with other pathogens occurred in 33{\%} and 56{\%} of NPAs and fecal samples, respectively, from patients with HBoV infection. Genomes of HBoVs from NPAs and fecal samples displayed minimal sequence variations. CONCLUSIONS: HBoV was detected in fecal specimens in children with acute gastroenteritis. A single lineage of HBoV was associated with both respiratory tract and enteric infections.},
	isbn = {0022-1899 (Print)$\backslash$r0022-1899 (Linking)},
	issn = {0022-1899},
	doi = {10.1086/521310},
	url = {http://jid.oxfordjournals.org/lookup/doi/10.1086/521310},
	author = {Lau, S.K.P. and Yip, C.C.Y. and Que, T. and Lee, R.A. and Au-Yeung, R.K.H. and Zhou, B. and So, Lok-yee and Lau, Yu-lung and Chan, Kwok-hung and Woo, Patrick C. Y. and Yuen, Kwok-yung}
}
