

@article {881,
	title = {Comparison of virus shedding after lived attenuated and pentavalent reassortant rotavirus vaccine.},
	journal = {Vaccine},
	volume = {32},
	number = {10},
	year = {2014},
	pages = {1199-1204},
	abstract = {Transmission of rotavirus vaccine or vaccine-reassortant strains to unvaccinated contacts has been reported. Therefore, it is essential to evaluate and characterize the nature of vaccine-virus shedding among rotavirus vaccine recipients. Two groups of healthy infants who received a complete course of {RotaTeq} {(RV5)} or Rotarix {(RV2)} were enrolled (between March 2010 and June 2011) to compare fecal shedding for one month after each vaccine dose. Shedding was assessed using both enzyme immunoassay {(EIA)} and real-time reverse transcription-polymerase chain reaction {(RT-PCR).} Eighty-seven infants (34 girls and 53 boys) were enrolled in the study. After the first vaccine dose, the peak time of virus shedding occurred between day 4 and day 7, with positive detection rates of 80-90\% by real-time {RT-PCR} and 20-30\% by {EIA.} In both groups, vaccine shedding occurred as early as one day and as late as 25-28 days. Mixed effects logistic regression analysis of real-time {RT-PCR} data showed no significant differences between two groups when shedding rates were compared after the first vaccine dose (odds ratio {[OR]} 1.26; P=0.71) or after the second vaccine dose (odds ratio {[OR]} 1.26; P=0.99). However, infants receiving {RV2} shed significantly higher viral loads than those receiving {RV5} when compared after the first vaccine dose {(P=0.001)} and after the second dose {(P=0.039).} In terms of shedding rates detected by real-time {RT-PCR,} vaccine uptake of {RV5} or {RV2} among infants in Taiwan was comparable. Clinical significance of higher shedding viral loads in {RV2} should be further observed.},
	doi = {10.1016/j.vaccine.2013.08.041},
	url = {http://dx.doi.org/10.1016/j.vaccine.2013.08.041},
	author = {Hsieh, Yu-Chia C and Wu, Fang-Tzy T and Hsiung, Chao A and Wu, Ho-Sheng S and Chang, Kuang-Yi Y and Huang, Yhu-Chering C}
}
