

@article {8223,
	title = {{Helicobacter pylori in the Canadian arctic: Seroprevalence and detection in community water samples}},
	journal = {American Journal of Gastroenterology},
	volume = {94},
	number = {7},
	year = {1999},
	pages = {1823{\textendash}1829},
	abstract = {OBJECTIVE: Many North American arctic communities are characterized by risk markers associated with Helicobacter pylori (H. pylori) infection, including overcrowded housing and inadequate water supply and sanitation systems. Our aim was to determine the seroprevalence of H. pylori infection in two traditional Inuit communities in the central Canadian arctic and to test for the presence of H. pylori, by polymerase chain reaction (PCR), in local water supplies.$\backslash$n$\backslash$nMETHODS: Samples of venous whole blood from adults and capillary blood from children were collected and analyzed by enzyme immunoassay and Helisal Rapid Test, respectively, for IgG antibody to H. pylori. Antibodies to CagA were detected by enzyme immunoassay, and ABO and Lewis antigens were also determined. Demographic and clinical information were collected by questionnaire. Water samples from each community were tested for H. pylori by PCR.$\backslash$n$\backslash$nRESULTS: One hundred-thirty (50.8{\%}) of 256 subjects from the two communities were positive for H. pylori IgG antibodies. Seropositive subjects were more likely to be male, compared with seronegative individuals (p = 0.01). Antibody status did not differ with respect to age, community, alcohol or cigarette use, number of persons per household, gastrointestinal complaints or previous investigations, medications, or presence of blood group O, Lewis a-b+. CagA antibodies were detected in 78 (61.9{\%}) of 126 H. pylori-seropositive subjects tested; however, 41 (35.3{\%}) of 116 H. pylori-seronegative subjects were also CagA positive. Water samples taken from the water delivery truck in Chesterfield Inlet and two lakes near Repulse Bay were positive for H. pylori.$\backslash$n$\backslash$nCONCLUSION: The seroprevalence of H. pylori in the study group was higher than rates in southern Canadian populations, but lower than the seroprevalence previously documented in a Canadian subarctic Indian (First Nations) community. The detection of H. pylori in local water supplies may indicate a natural reservoir for the organism or possible contamination from human sewage.},
	isbn = {0002-9270 (Print)$\backslash$r0002-9270 (Linking)},
	issn = {00029270},
	doi = {10.1111/j.1572-0241.1999.01212.x},
	author = {McKeown, Iris and Orr, Pamela and Macdonald, Sharon and Kabani, Amin and Brown, Rosemary and Coghlan, Gail and Dawood, Magdy and Embil, John and Sargent, Michael and Smart, Gerry and Bernstein, Charles N.}
}
