

@article {6321,
	title = {The impact of water, sanitation, and hygiene interventions on the health and well-being of people living with {HIV}: a systematic review},
	journal = {Journal of Acquired Immune Deficiency Syndromes (1999)},
	volume = {68 Suppl 3},
	year = {2015},
	month = {apr},
	pages = {S318{\textendash}330},
	abstract = {BACKGROUND: Access to improved water supply and sanitation is poor in low-income and middle-income countries. Persons living with HIV/AIDS (PLHIV) experience more severe diarrhea, hospitalizations, and deaths from diarrhea because of waterborne pathogens than immunocompetent populations, even when on antiretroviral therapy (ART). METHODS: We examined the existing literature on the impact of water, sanitation, and hygiene (WASH) interventions on PLHIV for these outcomes: (1) mortality, (2) morbidity, (3) retention in HIV care, (4) quality of life, and (5) prevention of ongoing HIV transmission. Cost-effectiveness was also assessed. Relevant abstracts and articles were gathered, reviewed, and prioritized by thematic outcomes of interest. Articles meeting inclusion criteria were summarized in a grid for comparison. RESULTS: We reviewed 3355 citations, evaluated 132 abstracts, and read 33 articles. The majority of the 16 included articles focused on morbidity, with less emphasis on mortality. Contaminated water, lack of sanitation, and poor hygienic practices in homes of PLHIV increase the risk of diarrhea, which can result in increased viral load, decreased CD4 counts, and reduced absorption of nutrients and antiretroviral medication. We found WASH programming, particularly water supply, household water treatment, and hygiene interventions, reduced morbidity. Data were inconclusive on mortality. Research gaps remain in retention in care, quality of life, and prevention of ongoing HIV transmission. Compared with the standard threshold of 3 times GDP per capita, WASH interventions were cost-effective, particularly when incorporated into complementary programs. CONCLUSIONS: Although research is required to address behavioral aspects, evidence supports that WASH programming is beneficial for PLHIV.},
	keywords = {Adult, Africa, Cost-Benefit Analysis, Developing Countries, Diarrhea, Health Resources, HIV Infections, Humans, Hygiene, India, Morbidity, Outcome Assessment (Health Care), Quality of Life, sanitation, Water Supply},
	issn = {1944-7884},
	doi = {10.1097/QAI.0000000000000487},
	author = {Yates, Travis and Lantagne, Daniele and Mintz, Eric and Quick, Robert}
}
