

@article {575,
	title = {Importance of enteric adenoviruses 40 and 41 in acute gastroenteritis in infants and young children},
	journal = {J Clin Microbiol},
	volume = {20},
	number = {3},
	year = {1984},
	note = {Uhnoo, I Wadell, G Svensson, L Johansson, M E Research Support, Non-U.S. Gov{\textquoteright}t United states Journal of clinical microbiology},
	pages = {365-72},
	type = {Journal Article},
	abstract = {In a prospective 1-year study of acute infantile gastroenteritis, adenoviruses were detected in the stools or by seroconversions, or both, in 56 of 416 (13.5\%) ill children. By use of DNA restriction enzyme analysis, enzyme immunoassay, and culture techniques, 33 of 56 (59\%) adenovirus specimens were identified as enteric adenoviruses 40 and 41 (Ad40 and Ad41). They were found as the sole recognizable cause of diarrhea in 30 of 416 (7.2\%) ill children and in 0 of 200 controls. Three additional ill children had enteric adenoviruses as a part of a dual infection. Evidence for established adenoviruses (Ad1 through Ad39) in gastroenteritis was found in 15 of 416 (3.6\%) ill children but also in 3 of 200 (1.5\%) controls. Eight adenovirus specimens remained untyped. Seroconversions were demonstrated in 17 of 18 (94\%) paired serum samples from patients shedding enteric adenoviruses. The predominant symptom of infections with enteric adenoviruses was diarrhea, with a mean duration of 8.6 days (Ad40) and 12.2 days (Ad41). One-third of the children with Ad41 infections had prolonged symptoms (greater than or equal to 14 days). The frequency of respiratory symptoms was low (21\%). The established adenoviruses presented a different clinical picture, characterized by diarrhea of shorter duration, higher fever, and significantly increased occurrence of respiratory symptoms (79\%). In conclusion, enteric adenoviruses appear to be an important cause of acute infantile gastroenteritis, second only to rotaviruses in this study.},
	keywords = {Acute Disease Adenoviridae/isolation \& purification Adenoviridae Infections/ etiology Adenovirus Infections, Electron Prospective Studies Rotavirus/immunology Seasons Sex Factors, Human/blood/ etiology Adolescent Age Factors Antibodies, Newborn Male Microscopy, Preschool DNA, Viral/analysis Antigens, Viral/analysis Child Child, Viral/analysis Enzyme-Linked Immunosorbent Assay Feces/microbiology Female Gastroenteritis/ etiology Hemagglutination Inhibition Tests Humans Infant Infant},
	issn = {0095-1137 (Print) 0095-1137 (Linking)},
	author = {Uhnoo, I. and Wadell, G. and Svensson, L. and Johansson, M. E.}
}
