

@article {569,
	title = {Incidence and treatment strategy for disseminated adenovirus disease after haploidentical stem cell transplantation},
	journal = {Ann Hematol},
	volume = {91},
	number = {8},
	year = {2012},
	note = {Taniguchi, Kyoko Yoshihara, Satoshi Tamaki, Hiroya Fujimoto, Tsuguto Ikegame, Kazuhiro Kaida, Katsuji Nakata, Jun Inoue, Takayuki Kato, Ruri Fujioka, Tatsuya Okada, Masaya Soma, Toshihiro Ogawa, Hiroyasu Evaluation Studies Germany Annals of hematology Ann Hematol. 2012 Aug;91(8):1305-12. doi: 10.1007/s00277-012-1440-3. Epub 2012 Apr 3.},
	pages = {1305-12},
	type = {Journal Article},
	abstract = {Adenovirus (AdV) infection is an emerging complication in patients undergoing allogeneic stem cell transplantation (SCT) and is closely associated with delayed immune reconstitution. In particular, disseminated AdV disease accompanies a high mortality. We retrospectively examined the incidence of AdV infection in patients undergoing unmanipulated haploidentical SCT. Following 121 transplantations in 110 patients, three had asymptomatic AdV viremia, three had localized AdV disease (hemorrhagic cystitis, HC), and seven had disseminated AdV disease (HC + viremia). The median time from transplantation to the onset of AdV-associated HC was 15 days (range 4-39), and the median time to the onset of disseminated AdV disease was 23 days (range 7-38). The cumulative incidence of AdV-associated HC was 8.3 \%, and that of disseminated AdV disease was 5.8 \%. AdV group B (type 11, type 34, or type 35) was detected in plasma samples from all the patients with disseminated AdV disease. Among them, three patients who received either cidofovir or donor lymphocyte infusion (DLI) alone progressed to pneumonia and died. The remaining four patients were treated with the combination of cidofovir and low-dose unmanipulated DLI, and all survived. We showed that disseminated AdV disease is a significant complication after haplo-SCT and that the combination of cidofovir and DLI is a promising treatment option.},
	keywords = {Adenovirus Infections, Homologous/adverse effects Viral Load Young Adult, Human/ epidemiology/ etiology/ therapy Adolescent Adult Aged Female Haplotypes Hematopoietic Stem Cell Transplantation/ adverse effects/methods Histocompatibility/physiology Humans Incidence Male Middle Aged Retrospective Studies Risk Factors Tissue Dono},
	issn = {1432-0584 (Electronic) 0939-5555 (Linking)},
	doi = {10.1007/s00277-012-1440-3},
	author = {Taniguchi, K. and Yoshihara, S. and Tamaki, H. and Fujimoto, T. and Ikegame, K. and Kaida, K. and Nakata, J. and Inoue, T. and Kato, R. and Fujioka, T. and Okada, M. and Soma, T. and Ogawa, H.}
}
