

@article {559,
	title = {Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality},
	journal = {Virology},
	volume = {409},
	number = {2},
	year = {2011},
	note = {Robinson, Christopher M Singh, Gurdeep Henquell, Cecile Walsh, Michael P Peigue-Lafeuille, Helene Seto, Donald Jones, Morris S Dyer, David W Chodosh, James EY013124-S1/EY/NEI NIH HHS/United States P30EY014104/EY/NEI NIH HHS/United States R01 EY013124/EY/NEI NIH HHS/United States R01 EY013124-09S1/EY/NEI NIH HHS/United States Case Reports Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov{\textquoteright}t United States Virology},
	pages = {141-7},
	type = {Journal Article},
	abstract = {Adenoviral infections are typically acute, self-limiting, and not associated with death. However, we present the genomic and bioinformatics analysis of a novel recombinant human adenovirus (HAdV-D56) isolated in France that caused a rare neonatal fatality, and keratoconjunctivitis in three health care workers who cared for the neonate. Whole genome alignments revealed the expected diversity in the penton base, hexon, E3, and fiber coding regions, and provided evidence for extensive recombination. Bootscan analysis confirmed recombination between HAdV-D9, HAdV-D26, HAdV-D15, and HAdV-D29 in the penton base and hexon proteins, centered around hypervariable loops within the putative proteins. Protein structure analysis of the fiber coding region revealed similarity with HAdV-D8, HAdV-D9, and HAdV-D53, possibly accounting for the ocular tropism of the virus. Based on these data, this virus appears to be a new HAdV-D type (HAdV-D56), underscoring the importance of recombination events in human adenovirus evolution and the emergence of new adenovirus pathogens.},
	keywords = {Adenoviruses, DNA Viral Proteins/genetics, Genetic Respiratory Tract Infections/mortality/ transmission/ virology Sequence Alignment Sequence Analysis, Human/ genetics/ isolation \& purification/pathogenicity Amino Acid Sequence Cluster Analysis Computational Biology DNA, Molecular Fatal Outcome France Genome, Newborn Keratoconjunctivitis/virology Molecular Sequence Data Phylogeny Recombination, Viral Humans Infant, Viral/chemistry/genetics Evolution},
	issn = {1096-0341 (Electronic) 0042-6822 (Linking)},
	author = {Robinson, C. M. and Singh, G. and Henquell, C. and Walsh, M. P. and Peigue-Lafeuille, H. and Seto, D. and M S Jones and Dyer, D. W. and Chodosh, J.}
}
