

@article {5552,
	title = {{Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers}},
	journal = {Clinical Immunology},
	volume = {108},
	number = {3},
	year = {2003},
	pages = {241{\textendash}247},
	abstract = {Norwalk virus-like particles (VLPs), made from recombinant capsid protein, are a promising vaccine. Thirty-six healthy adult volunteers received 250 ??g (n = 10), 500 ??g (n = 10), or 2000 ??g (n = 10) of orally administered VLP or placebo (n = 6). All vaccinees developed significant rises in IgA anti-VLP antibody-secreting cells. Ninety percent who received 250 ??g developed rises in serum anti-VLP IgG; neither the rates of seroconversion nor geometric mean titers increased at the higher doses. About 30-40{\%} of volunteers developed mucosal anti-VLP IgA. Lymphoproliferative responses and IFN-?? production were observed transiently among those who received 250 ??g or 500 ??g but not 2000 ??g of VLP. Studies to increase immunogenicity using a mucosal adjuvant are planned. ?? 2003 Elsevier Science (USA). All rights reserved.},
	keywords = {Human volunteers, Norovirus, Norwalk virus, Vaccine, Viruslike particles},
	isbn = {1521-6616 (Print)$\backslash$r1521-6616 (Linking)},
	issn = {15216616},
	doi = {10.1016/S1521-6616(03)00120-7},
	author = {Tacket, Carol O. and Sztein, Marcelo B. and Genevieve A Losonsky and Wasserman, Steven S. and Estes, Mary K.}
}
