

@article {551,
	title = {Abrupt emergence of diverse species B adenoviruses at US military recruit training centers},
	journal = {J Infect Dis},
	volume = {196},
	number = {10},
	year = {2007},
	note = {Metzgar, David Osuna, Miguel Kajon, Adriana E Hawksworth, Anthony W Irvine, Marina Russell, Kevin L Journal Article Multicenter Study Research Support, U.S. Gov{\textquoteright}t, Non-P.H.S. United States J Infect Dis. 2007 Nov 15;196(10):1465-73. Epub 2007 Oct 31.},
	pages = {1465-73},
	type = {Journal Article},
	abstract = {BACKGROUND: Adenoviruses (Ads) cause continuous outbreaks of acute respiratory disease (ARD) in US military training facilities. In 1996, the loss of vaccines targeting the dominant recruit-associated serotypes precipitated the reemergence of Ads in these populations. Between 1999 and 2002, serotype 4 accounted for >95\% of Ads isolated from recruits and for >50\% of ARD cases in training facilities (15,000 cases/year). METHODS: Ads (n=1867) collected between 2002 and 2006 from recruits with ARD at 8 military training facilities in the United States were serotyped by serum neutralization and polymerase chain reaction. RESULTS: The dominance of Ad4 continued through 2005, followed by a simultaneous emergence of diverse species B serotypes at the majority of sites. This included the subspecies B1 serotypes 3, 7, and 21 and the subspecies B2 serotype 14. Ad14 was the most prevalent species B serotype, appearing in high numbers at 3 sites and becoming dominant at 1. CONCLUSIONS: Subspecies B2 Ads have rarely been associated with ARD, and only in Eurasia. This survey represents the first report of AdB2-associated ARD in the Western Hemisphere. The simultaneous emergence of several species B Ads suggests a common external source (the civilian population) and a decrease in preexisting immunity to species B Ads.},
	keywords = {Adenovirus Infections, Emerging/epidemiology/prevention \& control/*virology DNA Primers DNA, Human/*classification/genetics/isolation \& purification Communicable Diseases, Human/epidemiology/prevention \& control/*virology Adenoviruses, Viral/analysis Humans Military Personnel/*statistics \& numerical data Neutralization Tests Polymerase Chain Reaction Prevalence Respiratory Tract Diseases/epidemiology/prevention \& control/*virology United States/epidemiology},
	issn = {0022-1899 (Print) 0022-1899},
	doi = {10.1086/522970},
	author = {Metzgar, D. and Osuna, M. and Kajon, A. E. and Hawksworth, A. W. and Irvine, M. and Russell, K. L.}
}
