

@article {533,
	title = {Molecular epidemiology and brief history of emerging adenovirus 14-associated respiratory disease in the United States},
	journal = {J Infect Dis},
	volume = {202},
	number = {1},
	year = {2010},
	note = {1537-6613 Kajon, Adriana E Lu, Xiaoyan Erdman, Dean D Louie, Janice Schnurr, David George, Kirsten St Koopmans, Marion P Allibhai, Taslim Metzgar, David Journal Article Research Support, U.S. Gov{\textquoteright}t, Non-P.H.S. United States J Infect Dis. 2010 Jul 1;202(1):93-103. doi: 10.1086/653083.},
	pages = {93-103},
	type = {Journal Article},
	abstract = {BACKGROUND: First isolated in the Netherlands in 1955 during an outbreak of acute respiratory disease (ARD) among military recruits, human adenovirus 14 (HAdV-14) has historically been considered rare. With no precedent of circulation in North America, HAdV-14 has been isolated from military and civilian cases of ARD of variable severity since 2003 in the United States. METHODS: Ninety-nine isolates from military and civilian cases from different geographic locations and circulation periods were characterized by restriction enzyme analysis of viral DNA and select gene sequencing. RESULTS: All examined viruses were found to be identical and to belong to a new genome type designated "HAdV-14p1" (formerly known as "14a"). Comparative alignments of E1A, hexon, and fiber gene sequences with other subspecies B2 HAdVs suggest that HAdV-14p1, like the closely related HAdV-11a, arose from recombination among similar HAdV-11 and HAdV-14 ancestral strains. A deletion of 2 amino acids in the knob region of the fiber protein is the only identified unique characteristic of HAdV-14p1. CONCLUSION: The current geographic distribution of HAdV-14p1 involves at least 15 states in the Unites States. The role of the fiber mutations in the recent emergence of HAdV-14p1 ARD in North America warrants further study.},
	keywords = {80 and over Child Child, Adenoviridae/classification/*genetics Adenovirus Infections, Emerging Disease Outbreaks Female Humans Infant Infant, Human/*epidemiology/*virology Adolescent Adult Aged, Newborn Male Middle Aged Military Personnel Molecular Epidemiology Population Surveillance United States Young Adult, Preschool Communicable Diseases},
	issn = {0022-1899},
	doi = {10.1086/653083},
	author = {Kajon, A. E. and Lu, X. and Erdman, D. D. and Louie, J. and Schnurr, D. and George, K. S. and Koopmans, M. P. and Allibhai, T. and Metzgar, D.}
}
