

@article {521,
	title = {Adenovirus 36 and obesity in children and adolescents},
	journal = {Pediatrics},
	volume = {126},
	number = {4},
	year = {2010},
	note = {1098-4275 Gabbert, Charles Donohue, Michael Arnold, John Schwimmer, Jeffrey B DK080506/DK/NIDDK NIH HHS/United States M01 RR000827/RR/NCRR NIH HHS/United States P60 MD00220/MD/NIMHD NIH HHS/United States R21 DK71486/DK/NIDDK NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov{\textquoteright}t United States Pediatrics. 2010 Oct;126(4):721-6. doi: 10.1542/peds.2009-3362. Epub 2010 Sep 20.},
	pages = {721-6},
	type = {Journal Article},
	abstract = {OBJECTIVE: The primary aim of this study was to assess the relationship between adenovirus 36 (AD36)-specific antibodies and obesity in children. METHODS: A cross-sectional study of children 8 to 18 years of age was performed. Children were classified according to BMI percentile as nonobese (<95th percentile) or obese (>/=95th percentile). The presence of AD36-specific neutralizing antibodies was assessed by using the serum neutralization assay. RESULTS: A total of 124 children (median age: 13.6 years) were studied. Of those children, 46\% were nonobese and 54\% were obese. AD36 positivity was present in 19 children (15\%). The majority of children found to be AD36-positive were obese (15 [78\%] of 19 children). AD36 positivity was significantly (P<.05) more frequent in obese children (15 [22\%] of 67 children) than nonobese children (4 [7\%] of 57 children). Among the subset of children who were obese, those who were AD36-positive had significantly larger anthropometric measures, including weight, BMI, waist circumference, and waist/height ratio. CONCLUSION: These data support an association of obesity and higher body weight with the presence of neutralizing antibodies to AD36 in children. If a cause-and-effect relationship is established, it would have considerable implications for the prevention and treatment of childhood obesity.},
	keywords = {Adenoviruses, Human/*immunology Adolescent Antibodies, Neutralizing/*blood Antibodies, Viral/*blood Antibody Specificity Body Mass Index Child Female Humans Male Neutralization Tests Obesity/*virology},
	issn = {0031-4005},
	doi = {10.1542/peds.2009-3362},
	author = {Gabbert, C. and Donohue, M. and Arnold, J. and Schwimmer, J. B.}
}
