

@article {3716,
	title = {Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine.},
	journal = {Reviews in medical virology},
	volume = {15},
	number = {1},
	year = {2005},
	pages = {29{\textendash}56},
	abstract = {A safe and effective rotavirus vaccine is urgently needed, particularly in developing countries. Critical to vaccine development and implementation is a knowledge base concerning the epidemiology of rotavirus G and P serotypes/genotypes throughout the world. The temporal and geographical distribution of human rotavirus G and P types was reviewed by analysing a total of 45571 strains collected globally from 124 studies reported from 52 countries on five continents published between 1989 and 2004. Four common G types \{\{\}(G1,\{\}\} G2, G3 and G4) in conjunction with P[8] or P[4] represented over 88\{\%\} of the strains analysed worldwide. In addition, serotype G9 viruses associated with P[8] or P[6] were shown to have emerged as the fourth globally important G type with the relative frequency of 4.1\{\%\}. When the global G and/or P type distributions were divided into five continents/subcontinents, several characteristic features emerged. For example, the \{\{\}P[8]G1\{\}\} represented over 70\{\%\} of rotavirus infections in North America, Europe and Australia, but only about 30\{\%\} of the infections in South America and Asia, and 23\{\%\} in Africa. In addition, in Africa (i) the relative frequency of G8 was as high as that of the globally common G3 or G4, (ii) P[6] represented almost one-third of all P types identified and (iii) 27\{\%\} of the infections were associated with rotavirus strains bearing unusual combinations such as \{\{\}P[6]G8\{\}\} or \{\{\}P[4]G8.\{\}\} Furthermore, in South America, uncommon G5 virus appeared to increase its epidemiological importance among children with diarrhea. Such findings have (i) confirmed the importance of continued active rotavirus strain surveillance in a variety of geographical settings and (ii) provided important considerations for the development and implementation of an effective rotavirus vaccine (e.g. a geographical \{\{\}P-G\{\}\} type adjustment in the formulation of next generation multivalent vaccines).},
	doi = {10.1002/rmv.448},
	url = {http://dx.doi.org/10.1002/rmv.448},
	author = {Santos, Norma and Hoshino, Yasutaka}
}
