

@article {3577,
	title = {Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta-analysis.},
	journal = {Reviews in Medical Virology},
	volume = {21},
	number = {2},
	year = {2011},
	pages = {89{\textendash}109},
	abstract = {<p>The efficacy of licensed rotavirus vaccines has only been shown against certain rotavirus group A \{\{\}(RV-A)\{\}\} types. It is critical to understand the burden of rotavirus gastroenteritis \{\{\}(RVGE)\{\}\} and its prevalent types to assess the potential impact of these vaccines in Latin America and the Caribbean \{\{\}(LA\{\&amp;\}C).\{\}\} We performed a systematic review and meta-analyses of all the available evidence reported from 1990 to 2009 on the burden of rotavirus disease and strains circulating in \{\{\}LA\{\&amp;\}C.\{\}\} Eligible studies\{\{\}\${\textbackslash}backslash\$textendash\{\}\}185 country-level reports, 174\{\&amp;\}\{\#\}x2009;951 faecal samples\{\{\}\${\textbackslash}backslash\$textendash\{\}\}were selected from \{\{\}MEDLINE,\{\}\} Cochrane Library, \{\{\}EMBASE,\{\}\} \{\{\}LILACS,\{\}\} regional Ministries of Health, \{\{\}PAHO,\{\}\} regional proceedings, doctoral theses, reference lists of included studies and consulting experts. Arc-sine transformations and \{\{\}DerSimonian-Laird\{\}\} random-effects model were used for meta-analyses. The proportion of gastroenteritis cases due to rotavirus was 24.3\{\%\} \{\{\}(95\{\%\}CI\{\}\} 22.3-26.4) and the incidence of \{\{\}RVGE\{\}\} was 170 per 1000 children-years \{\{\}(95\{\%\}CI\{\}\} 130-210). We estimated a global annual mortality for 22 countries of 88.2 \{\{\}(95\{\%\}CI\{\}\} 79.3-97.1) deaths per 100\{\&amp;\}\{\#\}x2009;000 under 5 years (47\{\&amp;\}\{\#\}x2009;000 \{\{\}deaths).The\{\}\} most common G type detected was G1 (34.2\{\%\}), followed by G9 (14.6\{\%\}), and G2 (14.4\{\%\}). The most common P types detected were P[8] (56.2\{\%\}), P[4] (22.1\{\%\}) and P[1] 5.4\{\%\}, and the most prevalent \{\{\}P-G\{\}\} type associations were \{\{\}P[8]G1\{\}\} 17.9\{\%\}, \{\{\}P[4]G2\{\}\} 9.1\{\%\} and \{\{\}P[8]G9\{\}\} 8.8\{\%\}. In the last 10 years, G9 circulation increased remarkably and G5 almost disappeared. More recently, G12 appeared and \{\{\}P[4]G2\{\}\} re-emerged. To our knowledge, this is the first meta-analysis of rotavirus infection and burden of disease in \{\{\}LA\{\&amp;\}C.\{\}\}</p>
},
	doi = {10.1002/rmv.682},
	url = {http://dx.doi.org/10.1002/rmv.682},
	author = {Linhares, Alexandre C and Stupka, Juan A and Ciapponi, Agust{\'\i}n and Bardach, Ariel E and Glujovsky, Demi{\'a}n and Aruj, Patricia K and Mazzoni, Agustina and Rodriguez, Jefferson A and Rearte, Anal{\'\i}a and Lanzieri, Tatiana M and Ortega-Barr{\'\i}a, Eduardo and Colindres, Romulo}
}
