

@article {3524,
	title = {Comparison of virus shedding after lived attenuated and pentavalent reassortant rotavirus vaccine.},
	journal = {Vaccine},
	volume = {32},
	number = {10},
	year = {2014},
	pages = {1199{\textendash}1204},
	abstract = {Transmission of rotavirus vaccine or vaccine-reassortant strains to unvaccinated contacts has been reported. Therefore, it is essential to evaluate and characterize the nature of vaccine-virus shedding among rotavirus vaccine recipients. Two groups of healthy infants who received a complete course of \{\{\}RotaTeq\{\}\} \{\{\}(RV5)\{\}\} or Rotarix \{\{\}(RV2)\{\}\} were enrolled (between March 2010 and June 2011) to compare fecal shedding for one month after each vaccine dose. Shedding was assessed using both enzyme immunoassay \{\{\}(EIA)\{\}\} and real-time reverse transcription-polymerase chain reaction \{\{\}(RT-PCR).\{\}\} Eighty-seven infants (34 girls and 53 boys) were enrolled in the study. After the first vaccine dose, the peak time of virus shedding occurred between day 4 and day 7, with positive detection rates of 80-90\{\%\} by real-time \{\{\}RT-PCR\{\}\} and 20-30\{\%\} by \{\{\}EIA.\{\}\} In both groups, vaccine shedding occurred as early as one day and as late as 25-28 days. Mixed effects logistic regression analysis of real-time \{\{\}RT-PCR\{\}\} data showed no significant differences between two groups when shedding rates were compared after the first vaccine dose (odds ratio \{\{\}[OR]\{\}\} 1.26; P=0.71) or after the second vaccine dose (odds ratio \{\{\}[OR]\{\}\} 1.26; P=0.99). However, infants receiving \{\{\}RV2\{\}\} shed significantly higher viral loads than those receiving \{\{\}RV5\{\}\} when compared after the first vaccine dose \{\{\}(P=0.001)\{\}\} and after the second dose \{\{\}(P=0.039).\{\}\} In terms of shedding rates detected by real-time \{\{\}RT-PCR,\{\}\} vaccine uptake of \{\{\}RV5\{\}\} or \{\{\}RV2\{\}\} among infants in Taiwan was comparable. Clinical significance of higher shedding viral loads in \{\{\}RV2\{\}\} should be further observed.},
	doi = {10.1016/j.vaccine.2013.08.041},
	url = {http://dx.doi.org/10.1016/j.vaccine.2013.08.041},
	author = {Hsieh, Yu-Chia C and Wu, Fang-Tzy T and Hsiung, Chao A and Wu, Ho-Sheng S and Chang, Kuang-Yi Y and Huang, Yhu-Chering C}
}
