

@article {2539,
	title = {Novel {NSP1} genotype characterised in an African camel {G8P[11]} rotavirus strain.},
	journal = {Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
	volume = {21},
	year = {2014},
	pages = {58-66},
	abstract = {Animal-human interspecies transmission is thought to play a significant role in influencing rotavirus strain diversity in humans. Proving this concept requires a better understanding of the complete genetic constellation of rotaviruses circulating in various animal species. However, very few whole genomes of animal rotaviruses, especially in developing countries, are available. In this study, complete genetic configuration of the first African camel rotavirus strain {(RVA/Camel-wt/SDN/MRC-DPRU447/2002/G8P[11])} was assigned a unique {G8-P[11]-I2-R2-C2-M2-A18-N2-T6-E2-H3} genotype constellation that has not been reported in other ruminants. It contained a novel {NSP1} genotype (genotype A18). The evolutionary dynamics of the genome segments of strain {MRC-DPRU447} were rather complex compared to those found in other camelids. Its genome segments 1, 3, 7-10 were closely related (\&gt;93\% nucleotide identity) to those of human-animal reassortant strains like {RVA/Human-tc/ITA/PA169/1988/G6P[14]} and {RVA/Human-wt/HUN/Hun5/1997/G6P[14],} segments 4, 6 and 11 shared common ancestry (\&gt;95\% nucleotide identity) with bovine rotaviruses like strains {RVA/Cow-wt/CHN/DQ-75/2008/G10P[11]} and {RVA/Cow-wt/KOR/KJ19-2/XXXX/G6P[7],} whereas segment 2 was closely related (94\% nucleotide identity) to guanaco rotavirus strain {RVA/Guanaco-wt/ARG/Rio\_Negro/1998/G8P[1].} Its genetic backbone consisted of {DS-1-like,} {AU-1-like,} artiodactyl-like and a novel A18 genotype. This suggests that strain {MRC-DPRU447} potentially emerged through multiple reassortment events between several mammalian rotaviruses of at least two genogroups or simply strain {MRC-DPRU447} display a unique progenitor genotypes. Close relationship between some of the genome segments of strain {MRC-DPRU447} to human rotaviruses suggests previous occurrence of reassortment processes combined with interspecies transmission between humans and camels. The whole genome data for strain {MRC-DPRU447} adds to the much needed animal rotavirus data from Africa which is limited at the moment.},
	doi = {10.1016/j.meegid.2013.10.002},
	url = {http://dx.doi.org/10.1016/j.meegid.2013.10.002},
	author = {Jere, Khuzwayo C and Esona, Mathew D and Ali, Yahia H and Peenze, Ina and Roy, Sunando and Bowen, Michael D and Saeed, Intisar K and Khalafalla, Abdelmelik I and Nyaga, Martin M and Mphahlele, Jeffrey and Steele, Duncan and Seheri, Mapaseka L}
}
