

@article {2532,
	title = {Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reassortment.},
	journal = {Journal of virology},
	volume = {84},
	number = {4},
	year = {2010},
	pages = {2013-2026},
	abstract = {Although few simian rotaviruses {(RVs)} have been isolated, such strains have been important for basic research and vaccine development. To explore the origins of simian {RVs,} the complete genome sequences of strains {PTRV} {(G8P[1]),} {RRV} {(G3P[3]),} and {TUCH} {(G3P[24])} were determined. These data allowed the genotype constellations of each virus to be determined and the phylogenetic relationships of the simian strains with each other and with nonsimian {RVs} to be elucidated. The results indicate that {PTRV} was likely transmitted from a bovine or other ruminant into pig-tailed macaques (its host of origin), since its genes have genotypes and encode outer-capsid proteins similar to those of bovine {RVs.} In contrast, most of the genes of rhesus-macaque strains, {RRV} and {TUCH,} have genotypes more typical of canine-feline {RVs.} However, the sequences of the canine and/or feline (canine/feline)-like genes of {RRV} and {TUCH} are only distantly related to those of modern canine/feline {RVs,} indicating that any potential transmission of a progenitor of these viruses from a canine/feline host to a simian host was not recent. The remaining genes of {RRV} and {TUCH} appear to have originated through reassortment with bovine, human, or other {RV} strains. Finally, comparison of {PTRV,} {RRV,} and {TUCH} genes with those of the vervet-monkey {RV} {SA11-H96} {(G3P[2])} indicates that {SA11-H96} shares little genetic similarity to other simian strains and likely has evolved independently. Collectively, our data indicate that simian {RVs} are of diverse ancestry with genome constellations that originated largely by interspecies transmission and reassortment with nonhuman animal {RVs.}},
	doi = {10.1128/JVI.02081-09},
	url = {http://dx.doi.org/10.1128/JVI.02081-09},
	author = {Matthijnssens, Jelle and Taraporewala, Zenobia F and Yang, Hongyan and Rao, Shujing and Yuan, Lijuan and Cao, Dianjun and Hoshino, Yasutaka and Mertens, Peter P and Carner, Gerry R and McNeal, Monica and Sestak, Karol and Van Ranst, Marc and Patton, John T}
}
