

@article {1714,
	title = {Impact of virus aggregation on inactivation by peracetic acid and implications for other disinfectants},
	journal = {Environ Sci Technol},
	volume = {45},
	number = {18},
	year = {2011},
	note = {Mattle, Michael J Crouzy, Benoit Brennecke, Moritz Wigginton, Krista R Perona, Paolo Kohn, Tamar eng Research Support, Non-U.S. Gov{\textquoteright}t Research Support, U.S. Gov{\textquoteright}t, Non-P.H.S. 2011/08/09 06:00 Environ Sci Technol. 2011 Sep 15;45(18):7710-7. doi: 10.1021/es201633s. Epub 2011 Aug 19.},
	pages = {7710-7},
	type = {Journal Article},
	abstract = {Viruses in wastewater and natural environments are often present as aggregates. The disinfectant dose required for their inactivation, however, is typically determined with dispersed viruses. This study investigates how aggregation affects virus inactivation by chemical disinfectants. Bacteriophage MS2 was aggregated by lowering the solution pH, and aggregates were inactivated by peracetic acid (PAA). Aggregates were redispersed before enumeration to obtain the residual number of individual infectious viruses. In contrast to enumerating whole aggregates, this approach allowed an assessment of disinfection efficiency which remains applicable even if the aggregates disperse in post-treatment environments. Inactivation kinetics were determined as a function of aggregate size (dispersed, 0.55 and 0.90 mum radius) and PAA concentration (5-103 mg/L). Aggregation reduced the apparent inactivation rate constants 2-6 fold. The larger the aggregate and the higher the PAA concentration, the more pronounced the inhibitory effect of aggregation on disinfection. A reaction-diffusion based model was developed to interpret the experimental results, and to predict inactivation rates for additional aggregate sizes and disinfectants. The model showed that the inhibitory effect of aggregation arises from consumption of the disinfectant within the aggregate, but that diffusion of the disinfectant into the aggregates is not a rate-limiting factor. Aggregation therefore has a large inhibitory effect if highly reactive disinfectants are used, whereas inactivation by mild disinfectants is less affected. Our results suggest that mild disinfectants should be used for the treatment of water containing viral aggregates.},
	keywords = {Chemical Peracetic Acid/*pharmacology Virus Inactivation/drug effects *Water Microbiology *Water Pollutants Water Purification, Disinfectants/*pharmacology Kinetics Levivirus/*drug effects/physiology Models},
	issn = {1520-5851 (Electronic) 0013-936X (Linking)},
	doi = {10.1021/es201633s},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21819042},
	author = {Mattle, M. J. and Crouzy, B. and Brennecke, M. and Wigginton, K. R. and Perona, P. and Kohn, T.}
}
