

@article {16604,
	title = {Advancing a multivalent {\textquoteright}{Pan}-anthelmintic{\textquoteright} vaccine against soil-transmitted nematode infections},
	journal = {Expert Rev Vaccines},
	volume = {13},
	number = {3},
	year = {2014},
	month = {mar},
	pages = {321{\textendash}31},
	abstract = {The Sabin Vaccine Institute Product Development Partnership is developing a Pan-anthelmintic vaccine that simultaneously targets the major soil-transmitted nematode infections, in other words, ascariasis, trichuriasis and hookworm infection. The approach builds off the current bivalent Human Hookworm Vaccine now in clinical development and would ultimately add both a larval Ascaris lumbricoides antigen and an adult-stage Trichuris trichiura antigen from the parasite stichosome. Each selected antigen would partially reproduce the protective immunity afforded by UV-attenuated Ascaris eggs and Trichuris stichosome extracts, respectively. Final antigen selection will apply a ranking system that includes the evaluation of expression yields and solubility, feasibility of process development and the absence of circulating antigen-specific IgE among populations living in helminth-endemic regions. Here we describe a five year roadmap for the antigen discovery, feasibility and antigen selection, which will ultimately lead to the scale-up expression, process development, manufacture, good laboratory practices toxicology and preclinical evaluation, ultimately leading to Phase 1 clinical testing.},
	keywords = {Ancylostomatoidea/immunology, Animals, Anthelmintics, Antigens, Ascariasis/immunology/*prevention \& control, Ascaris lumbricoides/immunology, Helminth/immunology, Hookworm Infections/immunology/*prevention \& control, Humans, Protozoan Vaccines/*immunology, Soil/parasitology, Trichuriasis/immunology/*prevention \& control, Trichuris/immunology},
	issn = {1744-8395 (Electronic) 1476-0584 (Linking)},
	doi = {10.1586/14760584.2014.872035},
	author = {Zhan, B. and Beaumier, C. M. and Briggs, N. and Jones, K. M. and Keegan, B. P. and Bottazzi, M. E. and Hotez, P. J.}
}
