

@article {16598,
	title = {Two quantitative trait loci influence whipworm ({Trichuris} trichiura) infection in a {Nepalese} population},
	journal = {J Infect Dis},
	volume = {197},
	number = {8},
	year = {2008},
	month = {apr},
	pages = {1198{\textendash}203},
	abstract = {BACKGROUND: Whipworm (Trichuris trichiura) infection is a soil-transmitted helminth infection that affects {\textgreater}1 billion people. It is a serious public health problem in many developing countries and can result in deficits in growth and cognitive development. In a follow-up study of significant heritability for whipworm infection, we conducted the first genome scan for quantitative trait loci (QTL) influencing the heritability of susceptibility to this important parasitic disease. METHODS: Whipworm egg counts were determined for 1,253 members of the Jirel population of eastern Nepal. All individuals in the study sample belonged to a single pedigree including {\textgreater}26,000 pairs of relatives that are informative for genetic analysis. RESULTS: Linkage analysis of genome scan data generated for the pedigree provided unambiguous evidence for 2 QTL influencing susceptibility to whipworm infection, one located on chromosome 9 (logarithm of the odds ratio [LOD] score, 3.35; genomewide P = .0138) and the other located on chromosome 18 (LOD score, 3.29; genomewide P = .0159). There was also suggestive evidence that 2 loci located on chromosomes 12 and 13 influenced whipworm infection. CONCLUSION: The results of this first genome scan for T. trichiura egg counts provides new information on the determinants of genetic predisposition to whipworm infection.},
	keywords = {*Quantitative Trait Loci, 80 and over, Adolescent, Adult, Aged, Animals, Child, Chromosome Mapping, Feces/parasitology, Female, Gastrointestinal Diseases/epidemiology/*genetics/*parasitology, Genetic Predisposition to Disease, Genome, Human, Humans, Lod Score, Male, Middle Aged, Nepal/epidemiology, Parasite Egg Count, Preschool, prevalence, Trichuriasis/epidemiology/*genetics/parasitology, Trichuris/*growth \& development},
	issn = {0022-1899 (Print) 0022-1899 (Linking)},
	doi = {10.1086/533493},
	author = {Williams-Blangero, S. and Vandeberg, J. L. and Subedi, J. and Jha, B. and Dyer, T. D. and Blangero, J.}
}
