

@article {16579,
	title = {Interleukin-10 and soil-transmitted helminth infections in {Honduran} children},
	journal = {BMC Res Notes},
	volume = {8},
	year = {2015},
	month = {feb},
	pages = {55},
	abstract = {{BACKGROUND: Soil-transmitted helminths (STH) establish chronic infections in the human intestine. The host reacts to these infections with a dominant T-helper type 2 cell (Th2) response that while attempting to control the worm population, can also provide an anti-inflammatory environment favourable for parasite survival. Regulatory cytokine interleukin 10 (IL-10) has been proposed as a key molecule involved in the attenuation of chronic inflammation and the ensuing tolerance for these helminth parasites. The objective of this study was to determine whether STH-infected children from an endemic community had increased circulating IL-10 levels when compared to non-infected children. RESULTS: A total of 39 children (25 boys and 14 girls, 7-15 years of age) were enrolled in study. Utilizing the Kato-Katz method to detect intestinal helminthiases, 10 children were non-infected and 29 were harbouring STH infections by Ascaris lumbricoides, Trichuris trichiura and/or hookworms. Of the 29 infected children, 11 had single-species infections and 18 were polyparasitized with two or three STH species. Serum samples from all 39 children were tested for IL-10 serum concentrations, out of which 12 had undetectable levels while 27 had levels ranging from 0.4-105 pg/mL. Excluding extreme outlying values, 25 samples had IL-10 concentration values ranging from 0.4 -7.2 pg/mL. Differences in IL-10 levels among non-parasitized, monoparasitized, and polyparasitized groups were not statistically significant. However, children infected with any of the three STH species investigated had higher IL-10 levels than non-parasitized children (geometric means: 0.89 pg/mL vs. 0.74 pg/mL},
	keywords = {Adolescent, Child, Female, Helminthiasis/blood/immunology/*parasitology/*transmission, Honduras, Humans, Interleukin-10/*blood, Male, Soil/*parasitology},
	issn = {1756-0500 (Electronic) 1756-0500 (Linking)},
	doi = {10.1186/s13104-015-1019-x},
	author = {Sanchez, A. L. and Mahoney, D. L. and Gabrie, J. A.}
}
