

@article {16501,
	title = {Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections},
	journal = {Trans R Soc Trop Med Hyg},
	volume = {96},
	number = {6},
	year = {2002},
	pages = {685{\textendash}90},
	abstract = {A randomized controlled trial comparing the efficacy of pyrantel-oxantel (10 mg/kg) with mebendazole (500 mg) was performed on 1329 schoolchildren aged 6-9 years on Pemba Island in September-October 2000 to evaluate alternative single-dose drugs for regular treatment of intestinal nematode infections. Both mebendazole and pyrantel-oxantel were very effective in eliminating Ascaris lumbricoides infection, inducing cure rates of more than 96\% and reducing the mean egg counts by more than 95\%. Both drugs had a moderate efficacy against Trichuris trichiura infection, but pyrantel-oxantel had a higher cure rate (31.5\% vs. 23.3\%, P {\textless} 0.01), though the reductions in egg counts did not differ significantly and were more than 80\%. Pyrantel-oxantel and mebendazole had a similar, poor efficacy in curing hookworm infections and had a moderate effect in reducing the egg counts by 67\% and 68\%, respectively. Pyrantel-oxantel (10 mg/kg) offers a valuable alternative to mebendazole as a single-dose treatment for the control of intestinal nematode infections in children in endemic areas of sub-Saharan Africa, due to its comparable efficacy, its low cost and its suitability for use in young children.},
	keywords = {Antinematodal Agents/*therapeutic use, Ascariasis/drug therapy, Child, Hookworm Infections/drug therapy, Humans, Intestinal Diseases, Nematode Infections/*drug therapy, Parasitic/*drug therapy, Pyrantel/*analogs \& derivatives/*therapeutic use, Soil/*parasitology, Treatment Outcome, Trichuriasis/drug therapy},
	issn = {0035-9203 (Print) 0035-9203 (Linking)},
	author = {Albonico, M. and Bickle, Q. and Haji, H. J. and Ramsan, M. and Khatib, K. J. and Montresor, A. and Savioli, L. and Taylor, M.}
}
