@article {15520, title = {Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni}, journal = {PLOS Neglected Tropical Diseases}, volume = {6}, number = {2}, year = {2012}, note = {Portela, Julien
Boissier, Jerome
Gourbal, Benjamin
Pradines, Vincent
Colliere, Vincent
Cosledan, Frederic
Meunier, Bernard
Robert, Anne
eng
Research Support, Non-U.S. Gov{\textquoteright}t
2012/02/22 06:00
PLoS Negl Trop Dis. 2012;6(2):e1474. doi: 10.1371/journal.pntd.0001474. Epub 2012 Feb 14.}, pages = {e1474}, abstract = {Schistosomiasis is among the most neglected tropical diseases, since its mode of spreading tends to limit the contamination to people who are in contact with contaminated waters in endemic countries. Here we report the in vitro and in vivo anti-schistosomal activities of trioxaquines. These hybrid molecules are highly active on the larval forms of the worms and exhibit different modes of action, not only the alkylation of heme. The synergy observed with praziquantel on infected mice is in favor of the development of these trioxaquines as potential anti-schistosomal agents.}, keywords = {Aminoquinolines/*administration \& dosage/*pharmacology, Animals, Anthelmintics/*administration \& dosage/*pharmacology, Drug Synergism, Female, Humans, Larva/drug effects, Male, Mice, Praziquantel/administration \& dosage/pharmacology, Schistosoma mansoni/*drug effects, Schistosomiasis mansoni/*drug therapy, Treatment Outcome}, isbn = {1935-2735 (Electronic)
1935-2727 (Linking)}, author = {Portela, J. and Boissier, J. and Gourbal, B. and Pradines, V. and Colliere, V. and Cosledan, F. and Meunier, B. and Robert, A.} }