@article {15511, title = {Granulomatous hypersensitivity to Schistosoma mansoni egg antigens in human schistosomiasis. II. In vitro granuloma modulation induced by polyclonal idiotypic antibodies}, journal = {J Immunol}, volume = {147}, number = {11}, year = {1991}, note = {Parra, J C
Gazzinelli, G
Goes, A M
Moyes, R B
Rocha, R
Colley, D G
Doughty, B L
eng
AI21776/AI/NIAID NIH HHS/
Research Support, Non-U.S. Gov{\textquoteright}t
Research Support, U.S. Gov{\textquoteright}t, Non-P.H.S.
Research Support, U.S. Gov{\textquoteright}t, P.H.S.
Baltimore, Md. : 1950
1991/12/01
J Immunol. 1991 Dec 1;147(11):3949-54.}, month = {Dec 1}, pages = {3949-54}, abstract = {We have previously reported on Id/anti-Id-receptor interactions in clinical human schistosomiasis. These findings support a hypothesis that anti-SEA cross-reactive Id develop in some patients during the course of a chronic infection and participate in regulation of anti-SEA cellular immune responses. We report here on experiments that extend those observations to the regulation of granulomatous hypersensitivity measured by an in vitro granuloma model. T cells from chronic intestinal schistosomiasis patients were stimulated in vitro with anti-SEA Id and assayed in an autologous in vitro granuloma assay for modulation of granuloma formation. These anti-SEA Id-reactive T cells were capable of regulating autologous in vitro granuloma formation. Both CD4 and CD8 T cells could be activated to regulate granuloma formation. This regulatory activity, initiated with stimulatory anti-SEA idiotypic antibodies, was antigenically specific and was dependent on the presence of intact F(ab{\textquoteright})2 Ig molecules. The ability to elicit this regulatory activity appears to be dose dependent and is more easily demonstrated in chronically infected intestinal patients or SEA-sensitized individuals. These data support the hypothesis that anti-SEA cross-reactive Id are important in regulating granulomatous hypersensitivity in chronic intestinal schistosomiasis patients and these cross-reactive Id appear to play a major role in cell-cell interactions that result in the regulation of anti-SEA cellular immune responses.}, keywords = {Animals, Antibodies, Anti-Idiotypic/*immunology, Antibodies, Helminth/immunology, Antigenic Modulation, Antigens, Helminth/*immunology, Granuloma/immunology, Humans, Hypersensitivity/*immunology, Immunoglobulin Fab Fragments/immunology, In Vitro Techniques, Lymphocyte Activation, Ovum, Schistosoma mansoni/*immunology, Schistosomiasis mansoni/*immunology, T-Lymphocytes/immunology}, isbn = {0022-1767 (Print)
0022-1767 (Linking)}, author = {Parra, J. C. and Gazzinelli, G. and Goes, A. M. and Moyes, R. B. and Rocha, R. and Colley, D. G. and Doughty, B. L.} }