@article {15503, title = {Cellular immune responses of schistosomiasis patients are altered by human immunodeficiency virus type 1 coinfection}, journal = {J Infect Dis}, volume = {184}, number = {4}, year = {2001}, note = {Mwinzi, P N
Karanja, D M
Colley, D G
Orago, A S
Secor, W E
eng
Research Support, Non-U.S. Gov{\textquoteright}t
2001/07/27 10:00
J Infect Dis. 2001 Aug 15;184(4):488-96. Epub 2001 Jul 18.}, month = {Aug 15}, pages = {488-96}, abstract = {In vitro studies suggest that CD4(+) cells with a T helper 2 (Th2) phenotype better support human immunodeficiency virus type 1 (HIV-1) replication than do cells of the Th1 phenotype. As a result, Th2-type immune responses may be substantially affected by HIV-1 coinfection. To test this hypothesis, a comparison was done of proliferation and cytokine production by peripheral blood mononuclear cells from patients with schistosomiasis who were positive or negative for HIV-1. Patients with schistosomiasis with HIV-1 coinfections had significantly lower interleukin (IL)-4 and IL-10 production than did HIV-1-negative individuals. In contrast, interferon-gamma production levels were similar between the 2 groups. Furthermore, in patients with HIV-1, a decrease in CD4(+) T cells was correlated with an increased Th1:Th2 cytokine production ratio. The effect of praziquantel treatment on proliferation and cytokine responses also differed between HIV-1 infection groups. Thus, HIV-1 infection affects immune response patterns of patients with schistosomiasis.}, keywords = {Adolescent, Adult, Animals, Anthelmintics/therapeutic use, CD4 Lymphocyte Count, Cells, Cultured, Cytokines/biosynthesis, HIV Infections/*complications, HIV-1/*immunology, Humans, Leukocytes, Mononuclear/*immunology, Lymphocyte Activation, Praziquantel/therapeutic use, Schistosoma mansoni/*immunology/isolation \& purification, Schistosomiasis mansoni/complications/drug therapy/*immunology}, isbn = {0022-1899 (Print)
0022-1899 (Linking)}, author = {Mwinzi, P. N. and Karanja, D. M. and Colley, D. G. and Orago, A. S. and Secor, W. E.} }