@article {15394, title = {Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes}, journal = {J Exp Med}, volume = {206}, number = {11}, year = {2009}, note = {Journal Article
Research Support, Non-U.S. Gov{\textquoteright}t
United States}, month = {Oct 26}, pages = {2321-8}, abstract = {Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus and schistosome infections. Hepatic fibrosis (HF) may develop either slowly or rapidly in schistosome-infected subjects. This depends, in part, on a major genetic control exerted by genes of chromosome 6q23. A gene (connective tissue growth factor [CTGF]) is located in that region that encodes a strongly fibrogenic molecule. We show that the single nucleotide polymorphism (SNP) rs9402373 that lies close to CTGF is associated with severe HF (P = 2 x 10(-6); odds ratio [OR] = 2.01; confidence interval of OR [CI] = 1.51-2.7) in two Chinese samples, in Sudanese, and in Brazilians infected with either Schistosoma japonicum or S. mansoni. Furthermore, SNP rs12526196, also located close to CTGF, is independently associated with severe fibrosis (P = 6 x 10(-4); OR = 1.94; CI = 1.32-2.82) in the Chinese and Sudanese subjects. Both variants affect nuclear factor binding and may alter gene transcription or transcript stability. The identified variants may be valuable markers for the prediction of disease progression, and identify a critical step in the development of HF that could be a target for chemotherapy.}, keywords = {*Genetic Predisposition to Disease, African Continental Ancestry Group/genetics, Agriculture/manpower, American Native Continental Ancestry Group/genetics, Animals, Asian Continental Ancestry Group/genetics, Brazil, Cell Line, China, Connective Tissue Growth Factor/*genetics, Electrophoretic Mobility Shift Assay, Fisheries/manpower, Humans, Liver Cirrhosis/complications/*genetics/*parasitology, Nuclear Proteins, Polymorphism, Single Nucleotide/*genetics, Protein Binding, RNA Stability, Schistosoma/physiology, Schistosomiasis/*complications/*genetics/parasitology, Sudan, Transcription, Genetic}, isbn = {1540-9538 (Electronic)
0022-1007 (Linking)}, author = {Dessein, A. and Chevillard, C. and Arnaud, V. and Hou, X. and Hamdoun, A. A. and Dessein, H. and He, H. and Abdelmaboud, S. A. and Luo, X. and Li, J. and Varoquaux, A. and Mergani, A. and Abdelwahed, M. and Zhou, J. and Monis, A. and Pitta, M. G. and Gasmelseed, N. and Cabantous, S. and Zhao, Y. and Prata, A. and Brandt, C. and Elwali, N. E. and Argiro, L. and Li, Y.} }