@article {15387, title = {Immunoregulation in human schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms}, journal = {Mem Inst Oswaldo Cruz}, volume = {82 Suppl 4}, year = {1987}, note = {Colley, D G
Parra, J C
Montesano, M A
Lima, M
Nascimento, E
Doughty, B L
Goes, A
Gazzinelli, G
eng
Research Support, Non-U.S. Gov{\textquoteright}t
BRAZIL
1987/01/01
Mem Inst Oswaldo Cruz. 1987;82 Suppl 4:105-9.}, pages = {105-9}, abstract = {Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab{\textquoteright})2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.}, keywords = {Animals, Antibodies, Helminth/*immunology, Antibodies, Monoclonal/immunology, Antigens, Helminth/*immunology, Humans, Immunoglobulin Fab Fragments/immunology, Immunoglobulin Idiotypes/immunology, Interleukin-1/pharmacology, Lymphokines/immunology, Ovum/immunology, Receptors, Interleukin-2/biosynthesis, Schistosoma mansoni/*immunology, Schistosomiasis mansoni/*immunology, T-Lymphocytes/immunology}, isbn = {0074-0276 (Print)
0074-0276 (Linking)}, author = {Colley, D. G. and Parra, J. C. and Montesano, M. A. and Lima, M. and Nascimento, E. and Doughty, B. L. and Goes, A. and Gazzinelli, G.} }