@article {15385, title = {Immune responses during human schistosomiasis mansoni. IX. T-lymphocyte subset analysis by monoclonal antibodies in hepatosplenic disease}, journal = {Scand J Immunol}, volume = {17}, number = {4}, year = {1983}, note = {Colley, D G
Katz, N
Rocha, R S
Abrantes, W
da Silva, A L
Gazzinelli, G
eng
Research Support, Non-U.S. Gov{\textquoteright}t
Research Support, U.S. Gov{\textquoteright}t, Non-P.H.S.
NORWAY
1983/04/01
Scand J Immunol. 1983 Apr;17(4):297-302.}, month = {Apr}, pages = {297-302}, abstract = {T lymphocyte immunoregulatory subsets (T4+ and T8+ cells) have been analysed in eight cases of hepatosplenic schistosomiasis mansoni, and compared to parallel analyses of seven intestinal Schistosoma mansoni-infected patients and four uninfected control subjects. The mean T4+:T8+ ratio in hepatosplenic cases was markedly less than observed in other groups (0.94 vs 1.86 vs 2.22, respectively). Proliferative responses stimulated by a soluble adult worm extract correlated directly with the observed T4:T8 ratios. Normal levels of E rosette-positive and surface immunoglobulin-bearing lymphoid cells were observed in intestinal patients, while hepatosplenic patients demonstrated normal B lymphocyte proportions but highly erratic E rosette-positive percentages. Curiously, in hepatosplenic patients the percentage of E rosette-positive cells often did not correlate with the proportion of T3+ cells.}, keywords = {Antibodies, Monoclonal/*immunology, Antibody Formation, Humans, Immunity, Cellular, Intestinal Diseases, Parasitic/immunology, Liver Diseases, Parasitic/*immunology, Monocytes/cytology, Rosette Formation, Schistosoma mansoni, Schistosomiasis/*immunology, Splenic Diseases/*immunology, T-Lymphocytes/*classification}, isbn = {0300-9475 (Print)
0300-9475 (Linking)}, author = {Colley, D. G. and Katz, N. and Rocha, R. S. and Abrantes, W. and da Silva, A. L. and Gazzinelli, G.} }