

@article {1355,
	title = {Chlorine inactivation of hepatitis E virus and human adenovirus 2 in water},
	journal = {J Water Health},
	volume = {12},
	number = {3},
	year = {2014},
	note = {Girones, Rosina Carratala, Anna Calgua, Byron Calvo, Miquel Rodriguez-Manzano, Jesus Emerson, Suzanne Intramural NIH HHS/United States Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov{\textquoteright}t England Journal of water and health J Water Health. 2014 Sep;12(3):436-42. doi: 10.2166/wh.2014.027.},
	pages = {436-42},
	type = {Journal Article},
	abstract = {Hepatitis E virus (HEV) is transmitted via the fecal-oral route and has been recognized as a common source of large waterborne outbreaks involving contaminated water in developing countries. Thus, there is the need to produce experimental data on the disinfection kinetics of HEV by chlorine in water samples with diverse levels of fecal contamination. Here, the inactivation of HEV and human adenovirus C serotype 2 (HAdV2), used as a reference virus, was monitored using immunofluorescence and quantitative reverse transcription polymerase chain reaction (RT-qPCR) assays. HEV has been shown to be susceptible to chlorine disinfection and presented equivalent kinetics to human adenoviruses. The C(t) values observed for a 2-log reduction of HEV were 0.41 in buffered demand-free water and 11.21 mg/L x min in the presence of 1\% sewage. The results indicate that the inactivation kinetics of HEV and HAdV2 are equivalent and support the use of chlorine disinfection as an effective strategy to control HEV waterborne transmission.},
	keywords = {Adenoviruses, Human/ drug effects/physiology Chlorine/ pharmacology Disinfectants/ pharmacology Disinfection/ methods Fluorescent Antibody Technique Hepatitis E virus/ drug effects/physiology Reverse Transcriptase Polymerase Chain Reaction Sewage/virology Virus Inacti},
	issn = {1477-8920 (Print) 1477-8920 (Linking)},
	doi = {10.2166/wh.2014.027},
	author = {Girones, R. and Carratala, A. and Calgua, B. and Calvo, M. and Rodriguez-Manzano, J. and Emerson, S.}
}
