@article {12298, title = {The Comprehensive Antibiotic Resistance Database}, journal = {Antimicrobial Agents and Chemotherapy}, volume = {57}, number = {7}, year = {2013}, note = {McArthur, Andrew G. Waglechner, Nicholas Nizam, Fazmin Yan, Austin Azad, Marisa A. Baylay, Alison J. Bhullar, Kirandeep Canova, Marc J. De Pascale, Gianfranco Ejim, Linda Kalan, Lindsay King, Andrew M. Koteva, Kalinka Morar, Mariya Mulvey, Michael R. O{\textquoteright}Brien, Jonathan S. Pawlowski, Andrew C. Piddock, Laura J. V. Spanogiannopoulos, Peter Sutherland, Arlene D. Tang, Irene Taylor, Patricia L. Thaker, Maulik Wang, Wenliang Yan, Marie Yu, Tennison Wright, Gerard D.
McArthur, Andrew/0000-0002-1142-3063; Piddock, Laura/0000-0003-1460-473X; Wright, Gerard/0000-0002-9129-7131}, month = {Jul}, pages = {3348-3357}, abstract = {

The field of antibiotic drug discovery and the monitoring of new antibiotic resistance elements have yet to fully exploit the power of the genome revolution. Despite the fact that the first genomes sequenced of free living organisms were those of bacteria, there have been few specialized bioinformatic tools developed to mine the growing amount of genomic data associated with pathogens. In particular, there are few tools to study the genetics and genomics of antibiotic resistance and how it impacts bacterial populations, ecology, and the clinic. We have initiated development of such tools in the form of the Comprehensive Antibiotic Research Database (CARD; http://arpcard.mcmaster.ca). The CARD integrates disparate molecular and sequence data, provides a unique organizing principle in the form of the Antibiotic Resistance Ontology (ARO), and can quickly identify putative antibiotic resistance genes in new unannotated genome sequences. This unique platform provides an informatic tool that bridges antibiotic resistance concerns in health care, agriculture, and the environment.

}, isbn = {0066-4804}, author = {McArthur, A. G. and Waglechner, N. and Nizam, F. and Yan, A. and Azad, M. A. and Baylay, A. J. and Bhullar, K. and Canova, M. J. and De Pascale, G. and Ejim, L. and Kalan, L. and King, A. M. and Koteva, K. and Morar, M. and Mulvey, M. R. and O{\textquoteright}Brien, J. S. and Pawlowski, A. C. and Piddock, L. J. V. and Spanogiannopoulos, P. and Sutherland, A. D. and Tang, I. and Taylor, P. L. and Thaker, M. and Wang, W. L. and Yan, M. and Yu, T. and Wright, G. D.} }