@article {12112, title = {Advancing a multivalent {\textquoteright}Pan-anthelmintic{\textquoteright} vaccine against soil-transmitted nematode infections}, journal = {Expert Review of Vaccines}, volume = {13}, number = {3}, year = {2014}, note = {Zhan, Bin
Beaumier, Coreen M
Briggs, Neima
Jones, Kathryn M
Keegan, Brian P
Bottazzi, Maria Elena
Hotez, Peter J
eng
Review
England
2014/01/08 06:00
Expert Rev Vaccines. 2014 Mar;13(3):321-31. doi: 10.1586/14760584.2014.872035. Epub 2014 Jan 6.}, month = {Mar}, pages = {321-31}, abstract = {

The Sabin Vaccine Institute Product Development Partnership is developing a Pan-anthelmintic vaccine that simultaneously targets the major soil-transmitted nematode infections, in other words, ascariasis, trichuriasis and hookworm infection. The approach builds off the current bivalent Human Hookworm Vaccine now in clinical development and would ultimately add both a larval Ascaris lumbricoides antigen and an adult-stage Trichuris trichiura antigen from the parasite stichosome. Each selected antigen would partially reproduce the protective immunity afforded by UV-attenuated Ascaris eggs and Trichuris stichosome extracts, respectively. Final antigen selection will apply a ranking system that includes the evaluation of expression yields and solubility, feasibility of process development and the absence of circulating antigen-specific IgE among populations living in helminth-endemic regions. Here we describe a five year roadmap for the antigen discovery, feasibility and antigen selection, which will ultimately lead to the scale-up expression, process development, manufacture, good laboratory practices toxicology and preclinical evaluation, ultimately leading to Phase 1 clinical testing.

}, keywords = {Ancylostomatoidea/immunology, Animals, Anthelmintics, Antigens, Helminth/immunology, Ascariasis/immunology/*prevention \& control, Ascaris lumbricoides/immunology, Hookworm Infections/immunology/*prevention \& control, Humans, Protozoan Vaccines/*immunology, Soil/parasitology, Trichuriasis/immunology/*prevention \& control, Trichuris/immunology}, isbn = {1744-8395 (Electronic)
1476-0584 (Linking)}, author = {Zhan, B. and Beaumier, C. M. and Briggs, N. and Jones, K. M. and Keegan, B. P. and Bottazzi, M. E. and Hotez, P. J.} }