@article {12106, title = {Two quantitative trait loci influence whipworm (Trichuris trichiura) infection in a Nepalese population}, journal = {The Journal of Infectious Diseases}, volume = {197}, number = {8}, year = {2008}, note = {Williams-Blangero, Sarah
Vandeberg, John L
Subedi, Janardan
Jha, Bharat
Dyer, Tom D
Blangero, John
eng
AI44406/AI/NIAID NIH HHS/
C06 RR017515-01A1/RR/NCRR NIH HHS/
R01 AI037091-08/AI/NIAID NIH HHS/
C06 RR017515/RR/NCRR NIH HHS/
C06 RR013556-01/RR/NCRR NIH HHS/
C06 RR013556/RR/NCRR NIH HHS/
MH59490/MH/NIMH NIH HHS/
R01 MH059490/MH/NIMH NIH HHS/
R37 MH059490-11/MH/NIMH NIH HHS/
R21 AI044406/AI/NIAID NIH HHS/
R21 AI044406-01A1/AI/NIAID NIH HHS/
R01 AI044406/AI/NIAID NIH HHS/
R37 MH059490/MH/NIMH NIH HHS/
AI37091/AI/NIAID NIH HHS/
R01 AI037091/AI/NIAID NIH HHS/
Research Support, N.I.H., Extramural
2008/05/09 09:00
J Infect Dis. 2008 Apr 15;197(8):1198-203. doi: 10.1086/533493.}, month = {Apr 15}, pages = {1198-203}, abstract = {BACKGROUND: Whipworm (Trichuris trichiura) infection is a soil-transmitted helminth infection that affects >1 billion people. It is a serious public health problem in many developing countries and can result in deficits in growth and cognitive development. In a follow-up study of significant heritability for whipworm infection, we conducted the first genome scan for quantitative trait loci (QTL) influencing the heritability of susceptibility to this important parasitic disease. METHODS: Whipworm egg counts were determined for 1,253 members of the Jirel population of eastern Nepal. All individuals in the study sample belonged to a single pedigree including >26,000 pairs of relatives that are informative for genetic analysis. RESULTS: Linkage analysis of genome scan data generated for the pedigree provided unambiguous evidence for 2 QTL influencing susceptibility to whipworm infection, one located on chromosome 9 (logarithm of the odds ratio [LOD] score, 3.35; genomewide P = .0138) and the other located on chromosome 18 (LOD score, 3.29; genomewide P = .0159). There was also suggestive evidence that 2 loci located on chromosomes 12 and 13 influenced whipworm infection. CONCLUSION: The results of this first genome scan for T. trichiura egg counts provides new information on the determinants of genetic predisposition to whipworm infection.}, keywords = {*Quantitative Trait Loci, Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Chromosome Mapping, Feces/parasitology, Female, Gastrointestinal Diseases/epidemiology/*genetics/*parasitology, Genetic Predisposition to Disease, Genome, Human, Humans, Lod Score, Male, Middle Aged, Nepal/epidemiology, Parasite Egg Count, prevalence, Trichuriasis/epidemiology/*genetics/parasitology, Trichuris/*growth \& development}, isbn = {0022-1899 (Print)
0022-1899 (Linking)}, author = {Williams-Blangero, S. and Vandeberg, J. L. and Subedi, J. and Jha, B. and Dyer, T. D. and Blangero, J.} }