@article {12034, title = {Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network}, journal = {Infection and Immunity}, volume = {78}, number = {7}, year = {2010}, note = {Figueiredo, Camila Alexandrina
Barreto, Mauricio L
Rodrigues, Laura C
Cooper, Philip J
Silva, Nivea Bispo
Amorim, Leila D
Alcantara-Neves, Neuza Maria
eng
072405/Wellcome Trust/United Kingdom
074679/Wellcome Trust/United Kingdom
088862/Wellcome Trust/United Kingdom
072405/Z/03/Z/Wellcome Trust/United Kingdom
Research Support, Non-U.S. Gov{\textquoteright}t
2010/04/21 06:00
Infect Immun. 2010 Jul;78(7):3160-7. doi: 10.1128/IAI.01228-09. Epub 2010 Apr 19.}, month = {Jul}, pages = {3160-7}, abstract = {Helminth infections have been associated with protection against allergy and autoimmune diseases. We investigated the effects of chronic infections with Ascaris lumbricoides and Trichuris trichiura (measured twice over a 5-year period) on cytokine and antibody responses. We collected blood from 1,060 children aged 4 to 11 years living in a poor urban area of Brazil and measured Th1 (gamma interferon [IFN-gamma]) and Th2 (interleukin-5 [IL-5] and IL-13) cytokines and the regulatory cytokine IL-10 in unstimulated and stimulated (with mitogen or A. lumbricoides antigens) cultures of peripheral blood leukocytes and levels of total IgE and anti-A. lumbricoides IgG4 and IgE in serum. Intestinal helminth infections were associated with an increased proportion of children producing IL-5 in response to A. lumbricoides and producing IL-10 spontaneously, especially among coinfected and chronically infected children. Helminth infections were associated with a generalized suppression of cytokine responses to mitogen. Levels of total IgE and anti-A. lumbricoides IgG4 and IgE were especially elevated in chronically infected children. In conclusion, intestinal helminth infections were associated with a typical Th2 immune response profile and with the induction of immune hyporesponsiveness that was associated with greater frequencies of the production of spontaneous IL-10.}, keywords = {Animals, Antibodies, Helminth/blood/immunology, Ascariasis/*immunology, Ascaris lumbricoides/*immunology, Child, Child, Preschool, Female, Humans, Immunity, Humoral/immunology, Immunoglobulin E/blood/immunology, Immunoglobulin G/blood/immunology, Interferon-gamma/blood/immunology, Interleukin-10/blood/immunology, Interleukin-13/blood/immunology, Interleukin-5/blood/immunology, Male, Trichuriasis/*immunology, Trichuris/*immunology}, isbn = {1098-5522 (Electronic)
0019-9567 (Linking)}, author = {Figueiredo, C. A. and Barreto, M. L. and Rodrigues, L. C. and Cooper, P. J. and Silva, N. B. and Amorim, L. D. and Alcantara-Neves, N. M.} }