@article {12009, title = {Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections}, journal = {Transactions of the Royal Society of Tropical Medicine and Hygiene}, volume = {96}, number = {6}, year = {2002}, note = {Albonico, Marco
Bickle, Quentin
Haji, Hamad J
Ramsan, Mahdi
Khatib, Khatib J
Montresor, Antonio
Savioli, Lorenzo
Taylor, Martin
eng
Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov{\textquoteright}t
England
2003/03/11 04:00
Trans R Soc Trop Med Hyg. 2002 Nov-Dec;96(6):685-90.}, month = {Nov-Dec}, pages = {685-90}, abstract = {

A randomized controlled trial comparing the efficacy of pyrantel-oxantel (10 mg/kg) with mebendazole (500 mg) was performed on 1329 schoolchildren aged 6-9 years on Pemba Island in September-October 2000 to evaluate alternative single-dose drugs for regular treatment of intestinal nematode infections. Both mebendazole and pyrantel-oxantel were very effective in eliminating Ascaris lumbricoides infection, inducing cure rates of more than 96\% and reducing the mean egg counts by more than 95\%. Both drugs had a moderate efficacy against Trichuris trichiura infection, but pyrantel-oxantel had a higher cure rate (31.5\% vs. 23.3\%, P \< 0.01), though the reductions in egg counts did not differ significantly and were more than 80\%. Pyrantel-oxantel and mebendazole had a similar, poor efficacy in curing hookworm infections and had a moderate effect in reducing the egg counts by 67\% and 68\%, respectively. Pyrantel-oxantel (10 mg/kg) offers a valuable alternative to mebendazole as a single-dose treatment for the control of intestinal nematode infections in children in endemic areas of sub-Saharan Africa, due to its comparable efficacy, its low cost and its suitability for use in young children.

}, keywords = {Antinematodal Agents/*therapeutic use, Ascariasis/drug therapy, Child, Hookworm Infections/drug therapy, Humans, Intestinal Diseases, Parasitic/*drug therapy, Nematode Infections/*drug therapy, Pyrantel/*analogs \& derivatives/*therapeutic use, Soil/*parasitology, Treatment Outcome, Trichuriasis/drug therapy}, isbn = {0035-9203 (Print)
0035-9203 (Linking)}, author = {Albonico, M. and Bickle, Q. and Haji, H. J. and Ramsan, M. and Khatib, K. J. and Montresor, A. and Savioli, L. and Taylor, M.} }