

@article {11788,
	title = {{Sequential development of the immune response in rainbow trout Oncorhynchus mykiss (Walbaum, 1792) to experimental plerocercoid infections of Diphyllobothrium dendriticum (Nitzsch, 1824)}},
	journal = {Journal of Parasitology},
	volume = {104},
	number = {01},
	year = {1992},
	pages = {169{\textendash}178},
	abstract = {<p>Development of the inflammatory response of rainbow trout to experimental infections with Diphyllobothrium dendriticum plerocercoids is described using light and electron microscopy. The cellular response to plerocercoids occurred within 2 weeks post-infection (p.i.). This was followed by an increase in leucocyte numbers during weeks 3-6 p.i., with full encapsulation of plerocercoids by week 6 p.i. Neutrophils were the first leucocytes to engage the developing plerocercoid, followed by large influxes of macrophages which transformed into epithelioid cells. With longer times p.i. the accumulation of different leucocyte types increased, and a blood vascular network developed. Full development of the composite cyst was characterized by fibroplasia, particularly at the periphery of the cyst, and the subsequent deposition of a collagenous tissue matrix. Enzyme-linked immunosorbent assay {\{}(ELISA){\}} examination of serum samples taken over the 20 week period showed that specific {\{}anti-D.{\}} dendriticum antibody titres were first detected at 5 weeks p.i. and increased to a maximum by 11 weeks p.i.</p>
},
	issn = {0031-1820},
	doi = {10.1017/S0031182000060911},
	author = {Sharp, G and Pike, A and Secombes, C}
}
