

@article {10978,
	title = {Soil-{Transmitted} {Helminth} {Reinfection} after {Drug} {Treatment}: {A} {Systematic} {Review} and {Meta}-{Analysis}},
	journal = {PLOS Neglected Tropical Diseases},
	volume = {6},
	number = {5},
	year = {2012},
	month = {may},
	pages = {e1621},
	abstract = {Author Summary Infections with soil-transmitted helminths (the roundworm Ascaris lumbricoides, the whipworm Trichuris trichiura, and hookworm) affect over 1 billion people, particularly rural communities in the developing world. The global strategy to control soil-transmitted helminth infections is {\textquoteleft}preventive chemotherapy{\textquoteright}, which means large-scale administration of anthelmintic drugs to at-risk populations. However, because reinfection occurs after treatment, {\textquoteleft}preventive chemotherapy{\textquoteright} must be repeated regularly. Our systematic review and meta-analysis found that at 3, 6, and 12 months after treatment, A. lumbricoides prevalence reached 26\% (95\% confidence interval (CI): 16{\textendash}43\%), 68\% (95\% CI: 60{\textendash}76\%) and 94\% (95\% CI: 88{\textendash}100\%) of pretreatment levels, respectively. For T. trichiura, respective reinfection prevalence at these time points were 36\% (95\% CI: 28{\textendash}47\%), 67\% (95\% CI: 42{\textendash}100\%), and 82\% (95\% CI: 62{\textendash}100\%); and for hookworm, 30\% (95\% CI: 26{\textendash}34\%), 55\% (95\% CI: 34{\textendash}87\%), and 57\% (95\% CI: 49{\textendash}67\%). Prevalence and intensity of reinfection were positively correlated with pretreatment infection status. Our results suggest a frequent anthelmintic drug administration to maximize the benefit of preventive chemotherapy. Moreover, an integrated control strategy, consisting of preventive chemotherapy combined with health education and environmental sanitation is needed to interrupt transmission of soil-transmitted helminths.},
	doi = {10.1371/journal.pntd.0001621},
	url = {https://doi.org/10.1371/journal.pntd.0001621},
	author = {Jia, Tie-Wu and Melville, Sara and Utzinger, J{\"u}rg and King, Charles H. and Zhou, Xiao-Nong}
}
