

@article {10026,
	title = {{Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections.}},
	journal = {mBio},
	volume = {4},
	number = {3},
	year = {2013},
	month = {jan},
	pages = {e00231{\textendash}13},
	abstract = {Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4{\%} of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58{\%}) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus.},
	issn = {2150-7511},
	doi = {10.1128/mBio.00231-13},
	author = {Tan, Le Van and H R van Doorn and Ho DT Nghia and Tran TH Chau and Le TP Tu and de Vries, Michel and Canuti, Marta and Deijs, Martin and Jebbink, Maarten F and Baker, Stephen and Bryant, Juliet E and Tham, Nguyen Thi and BKrong, Nguyen Thi Thuy Chinh and Boni, Maciej F and Loi, Tran Quoc and Phuong, Le Thi and Verhoeven, Joost T P and Crusat, Martin and Jeeninga, Rienk E and Schultsz, Constance and Chau, Nguyen Van Vinh and Hien, Tran Tinh and van der Hoek, Lia and Farrar, Jeremy and de Jong, Menno D}
}
